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Search Results for " Tyrosine kinase IN 1 "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T5466	Tyrosine kinase-IN-1		VEGFR , FGFR , FLT , PDGFR
	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）		VEGFR , FGFR , FLT , PDGFR
T14692	BMX-IN-1	BMX kinase inhibitor	BTK
	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 ...		BTK
TQ0230	BTK IN-1	SNS062 analog	BTK
	BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).		BTK
T3059	ALK-IN-1	AP26113,Brigatinib,AP26113-analog	EGFR , IGF-1R , ALK
	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.		EGFR , IGF-1R , ALK
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T23504	VEGFR-IN-1	VEGFR Tyrosine Kinase Inhibitor II	Others
	VEGFR inhibitor		Others
T21785	AG957		Bcr-Abl
	Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].		Bcr-Abl
T60220	ROS kinases-IN-1		ROS Kinase
	ROS kinases-IN-1 is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity.		ROS Kinase
T4409	Gilteritinib	ASP2215	FLT , TAM Receptor , c-Kit
	Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an...		FLT , TAM Receptor , c-Kit
T3337	Ddr1-In-1		Discoidin Domain Receptor (DDR)
	DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2.		Discoidin Domain Receptor (DDR)
T16730	Remibrutinib		BTK
	Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticar...		BTK
T3980	Su1498	Tyrphostin SU 1498,AG 1498	VEGFR
	Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,...		VEGFR
T3211	Midostaurin	N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251	Others , PKC
	PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...		Others , PKC
T9843	FLT3-IN-16
	FLT3-IN-16 exhibits potent inhibitory activity against FLT3 tyrosine kinase with an IC 50 of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia [1].
T4182	Lavendustin B		Tyrosinase , transporter , HIV Protease
	Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).		Tyrosinase , transporter , HIV Protease
T22424	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea		Apoptosis , STAT
	SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular ca...		Apoptosis , STAT
T4075	Sulfatinib	KDR-IN-1	VEGFR , FGFR , HER
	Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to 24 nM.		VEGFR , FGFR , HER
T60197	UNC 1025		Others
	UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony format...		Others
T79888	EGFR-IN-87		EGFR
	EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750, EGFR_L858R/T790M, and EGFR_WT, respectively, in A431 cells. It ...		EGFR
T2500	Cediranib	AZD2171,NSC-732208	VEGFR , FLT , PDGFR , c-Kit , Autophagy
	Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit...		VEGFR , FLT , PDGFR , c-Kit , Autophagy
T77620	LMTK3-IN-1		c-Met/HGFR
	Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway. LMTK3-IN-1 has shown anticancer activity in a variety of cancer c...		c-Met/HGFR
T10534	BI-4020		EGFR
			EGFR
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T61730	Tyrosine kinase-IN-4
	Tyrosine kinase-IN-4 (EXAMPLE 107) is a protein tyrosine kinase inhibitor [1].
T39698	Gemnelatinib
	Gemnelatinib (WO2018077227, implementation example 1) is a tyrosine kinase inhibitor with potential applications in cancer research.
T10488	BCR-ABL-IN-1		Bcr-Abl
	BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.		Bcr-Abl
T79612	Tyrosine kinase-IN-6		c-Met/HGFR
	Tyrosine kinase-IN-6 is a potent inhibitor of RON splice variants, demonstrating significant anticancer and antineoplastic effects [1].		c-Met/HGFR
T8888	Lck-IN-1
	Lck-IN-1 is a potent inhibitor of lymphocyte protein tyrosine kinase (Lck) [1].
T11707	JAK2/FLT3-IN-1		JNK
	JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, F...		JNK
T78943	Syk-IN-7		Syk
	Syk-IN-7 (compound 17) acts as an inhibitor of spleen tyrosine kinase (SYK) [1].		Syk
T71400	Quizartinib HCl
	Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III recept...
T79163	RET-IN-24
	RET-IN-24 (Compound 26) is a selective inhibitor of RET tyrosine kinase, demonstrating antitumor activity [1].
T12610L	3-Hydroxy Midostaurin	CGP52421	FLT
	3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in culture medium and 9.8 μM in plasma. Though less selective, it ...		FLT
T61177	NSC114126
	NSC114126 is a highly effective and orally bioavailable inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR-TK). This compound exhibits robust antiproliferative properties, making it a...
T1656L	Vandetanib Fumarate	HSDB 8198,Zactima,Caprelsa,ZD 6474,Vandetanib
	Vandetanib Fumarate is an orally available tyrosine kinase inhibitor. Vandetanib Fumarate works by blocking RET (REarranged during Transfection), vascular endothelial growth factor receptor (VEGFR-2, VEGFR-3), and epider...
T61329	HP1142
	HP1142 is a highly effective and specific inhibitor targeting the FLT3 receptor tyrosine kinase, with a particular affinity for its mutant variant FLT3/ITD. It exhibits a benzoimidazole scaffold-based structure, making i...
T70202	DDR1-IN-1 dihydrochloride
	DDR1-IN-1 dihydrochloride is a selective and potent inhibitor of the DDR1 receptor tyrosine kinase, exhibiting an IC50 of 105 nM. It demonstrates fourfold reduced potency against DDR2, with an IC50 of 413 nM.
T72574	Axl/Mer/CSF1R-IN-1
	Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.
T78209	Nedometinib		MEK
	Nedometinib, a tyrosine kinase inhibitor, specifically targets MEK1 and exhibits antineoplastic effects. It is utilized in research related to dermatosis, cutaneous fibroneruroma, and neurofibromatosis [1].		MEK
T83218	ABBV-712		JAK
	ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases [1].		JAK
T79969	Axl-IN-16		TAM Receptor
	Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor tyrosine kinase expression [1].		TAM Receptor
T79859	TIE-2/VEGFR-2 kinase-IN-4
	TIE-2/VEGFR-2 kinase-IN-4, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting inhibitory concentration (IC50) values of 5.2 nM and 5.1 nM, respectively...
T40785	Gefitinib impurity 1
	Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM). This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 5...
T35915	Erlotinib-13C6	Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumo...
T35777	Nodularin
	The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatot...
T28874	SU11652	SU-11652,SU 11652
	SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGF...
T67442	CGP-53716
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase i...
T79858	TIE-2/VEGFR-2 kinase-IN-3
	TIE-2/VEGFR-2 kinase-IN-3, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting IC50 values of 6.9 nM and 3.5 nM, respectively. This compound is useful f...
T36429	Dihydrodiol-Ibrutinib
	PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A. 1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et...
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine recept...

Compounds

Tyrosine kinase-IN-1

T5466

Synonym:

Target: VEGFR, FGFR, FLT, PDGFR

BMX-IN-1

T14692

Synonym: BMX kinase inhibitor

Target: BTK

BTK IN-1

TQ0230

Synonym: SNS062 analog

Target: BTK

ALK-IN-1

T3059

Synonym: AP26113,Brigatinib,AP26113-analog

Target: EGFR, IGF-1R, ALK

SKLB4771

T2051

Synonym: FLT3-IN-1,FLT3-IN-1

Target: FLT

VEGFR-IN-1

T23504

Synonym: VEGFR Tyrosine Kinase Inhibitor II

Target: FLT, TAM Receptor, c-Kit

Ddr1-In-1

T3337

Synonym:

Target: Discoidin Domain Receptor (DDR)

Synonym: Tyrphostin SU 1498,AG 1498

Target: VEGFR

Midostaurin

T3211

Synonym: N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251

Target: Tyrosinase, transporter, HIV Protease

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

T22424

Synonym:

Target: Apoptosis, STAT

Sulfatinib

T4075

Synonym: KDR-IN-1

Target: VEGFR, FGFR, HER

Synonym: AZD2171,NSC-732208

Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy

Syk Inhibitor II hydrochloride

T9543

Synonym:

Target: Others

Tyrosine kinase-IN-4

Tyrosine kinase-IN-6

3-Hydroxy Midostaurin

Synonym: HSDB 8198,Zactima,Caprelsa,ZD 6474,Vandetanib

DDR1-IN-1 dihydrochloride

TIE-2/VEGFR-2 kinase-IN-4

Synonym: Erlotinib-13C6

Synonym: SU-11652,SU 11652

TIE-2/VEGFR-2 kinase-IN-3

T79858

Synonym:

Target:

Dihydrodiol-Ibrutinib

カタログ番号	製品名	別名	ターゲット
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R
T83411	2,3,4,6,8-Pentahydroxy-1-methylxanthone
	2,3,4,6,8-Pentahydroxy-1-methylxanthone, a xanthone derivative of Wardomyces anomalus, exhibits significant antioxidant activities and functions as an inhibitor of the p56 lck tyrosine kinase. It has potential applicatio...

天然物製品

Picropodophyllotoxin

T3S0027

Synonym: AXL 1717,Picropodophyllin

Target: IGF-1R

2,3,4,6,8-Pentahydroxy-1-methylxanthone

T83411

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00412	VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ...
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ...
TMPY-04125	PTP1B Protein, Human, Recombinant (His)	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c...
TMPJ-00375	HGF Protein, Human, Recombinant (His)	Human	HEK293 Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti...
TMPK-00793	LTK Potein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase that belongs to the insulin receptor family. LTK is mainly expressed in pre B cells and brain. LTK Potein, Mouse, Recombinant (His) is expressed in HEK293 mam...
TMPK-00863	LTK Potein, Human, Recombinant (His)	Human	HEK293 Cells
	Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase that belongs to the insulin receptor family. LTK is mainly expressed in pre B cells and brain. LTK Potein, Human, Recombinant (His) is expressed in HEK293 mam...
TMPY-04391	Lyn Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many f...
TMPK-00454	VEGFR2/KDR Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migratio...
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain ...
TMPY-01910	TIE1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that ...
TMPK-00410	AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00408	AXL Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPK-00407	AXL Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpre...
TMPJ-00252	SIRP beta 1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Signal-regulatory protein beta-1 (SIRPB1, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glyco...
TMPK-00417	MERTK/Mer Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 /...
TMPK-00452	HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled	Human	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and ...
TMPK-00418	MERTK/Mer Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mu...
TMPK-00453	HER3/ERBB3 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and ...
TMPH-00322	Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His)	Calloselasma rhodostoma	P. pastoris (Yeast)
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ...
TMPY-04380	DYRK3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase...
TMPH-00320	Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His)	Calloselasma rhodostoma	P. pastoris (Yeast)
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ...
TMPH-00321	Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His & SUMO)	Calloselasma rhodostoma	E. coli
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ...
TMPY-01360	FGFRL1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Fibroblast growth factor receptor-like 1 (FGFRL1) also known as Fibroblast growth factor receptor 5 (FGFR5), is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserv...
TMPH-00323	Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His & Myc)	Calloselasma rhodostoma	E. coli
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen ...
TMPY-04388	BLK Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organ...
TMPY-02708	NRG4 Protein, Human, Recombinant	Human	E. coli
	NRG4 (neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have dive...
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP)	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosph...
TMPY-02388	SIRP beta 1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoprotein...
TMPJ-00424	EphB2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Ephrin type-B receptor 2(EPHB2) belongs to the protein kinase superfamily and Ephrin receptor subfamily. EPHB2 contains 1 Eph LBD domain, 2 fibronectin type-III domains, 1 protein kinase domain and 1 SAM domain. Ephrin r...
TMPJ-00448	NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)	Human	E. coli
	Pro-neuregulin-1,Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand f...
TMPK-00455	IGF1R/CD221 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00658	IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00456	IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated	Human	HEK293 Cells
	The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPY-02555	VSTM1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	V-set and transmembrane domain containing 1 (VSTM1) is a protein containing the V-set domains. V-set domains are immunoglobulin-like domains resembling the antibody variable region. V-set domains are found in many kinds ...
TMPY-02563	VSTM1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	V-set and transmembrane domain containing 1 (VSTM1) is a protein containing the V-set domains. V-set domains are immunoglobulin-like domains resembling the antibody variable region. V-set domains are found in many kinds ...
TMPJ-00403	EphB1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Ephrin Type-B Receptor 1 (EPHB1) is a single-pass type I membrane protein that belongs to the Ephrin-B family of receptor tyrosine kinases that is involved in embryonic nervous and vascular system development. EPHB1/EPHT...
TMPJ-00978	PIP4K2A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain...
TMPJ-00712	MPZL1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface ...
TMPJ-00224	EFNB2 Protein, Mouse, Recombinant (hFc & His)	Mouse	HEK293 Cells
	Ephrin-B2 is a single-pass type I membrane protein and it contains 1 ephrin RBD (ephrin receptor-binding) domain. Ephrin-B2 belongs to the ephrin (EPH) family and it is cell surface transmembrane ligand for Eph receptors...
TMPY-02849	WIF1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein that binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-lik...
TMPJ-00290	GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two s...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His)	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 dis...
TMPJ-01418	CSF1R Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPJ-01419	CSF1R Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPJ-01290	Neurturin Protein, Human, Recombinant	Human	E. coli
	Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is expressed in both neuronal and nonneuronal tissues. Simila...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&...
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293 Cells
	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293 Cells
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
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VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

TMPJ-00412

Species: Human

Expression System: HEK293 Cells

RON/CD136 Protein, Human, Recombinant (His)

TMPY-02028

Species: Human

Expression System: HEK293 Cells

PTP1B Protein, Human, Recombinant (His)

TMPY-04125

Species: Human

Expression System: E. coli

HGF Protein, Human, Recombinant (His)

TMPJ-00375

Species: Human

Expression System: HEK293 Cells

LTK Potein, Mouse, Recombinant (His)

TMPK-00793

Species: Mouse

Expression System: HEK293 Cells

LTK Potein, Human, Recombinant (His)

TMPK-00863

Species: Human

Expression System: HEK293 Cells

Lyn Protein, Human, Recombinant (GST)

TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

VEGFR2/KDR Protein, Human, Recombinant (His & Avi)

TMPK-00454

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & Avi)

TMPK-00457

Species: Human

Expression System: HEK293 Cells

TIE1 Protein, Human, Recombinant (His)

TMPY-01910

Species: Human

Expression System: HEK293 Cells

AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

TMPK-00410

Species: Human

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00408

Species: Human

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (His & Avi)

TMPK-00407

Species: Human

Expression System: HEK293 Cells

SIRP beta 1 Protein, Human, Recombinant (His)

TMPJ-00252

Species: Human

Expression System: HEK293 Cells

MERTK/Mer Protein, Human, Recombinant (His)

TMPK-00417

Species: Human

Expression System: HEK293 Cells

YES1 Protein, Human, Recombinant (His & GST)

TMPY-04411

Species: Human

Expression System: Baculovirus Insect Cells

HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled

TMPK-00452

Species: Human

Expression System: HEK293 Cells

MERTK/Mer Protein, Human, Recombinant (mFc)

TMPK-00418

Species: Human

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Human, Recombinant (His & Avi)

TMPK-00453

Species: Human

Expression System: HEK293 Cells

Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His)

TMPH-00322

Species: Calloselasma rhodostoma

Expression System: P. pastoris (Yeast)

DYRK3 Protein, Human, Recombinant (His & GST)

TMPY-04380

Species: Human

Expression System: Baculovirus Insect Cells

Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His)

TMPH-00320

Species: Calloselasma rhodostoma

Expression System: P. pastoris (Yeast)

Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His & SUMO)

TMPH-00321

Species: Calloselasma rhodostoma

Expression System: E. coli

FGFRL1 Protein, Mouse, Recombinant (His)

TMPY-01360

Species: Mouse

Expression System: HEK293 Cells

Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His & Myc)

TMPH-00323

Species: Calloselasma rhodostoma

Expression System: E. coli

BLK Protein, Human, Recombinant (GST)

TMPY-04388

Species: Human

Expression System: Baculovirus Insect Cells

NRG4 Protein, Human, Recombinant

TMPY-02708

Species: Human

Expression System: E. coli

DUSP14 Protein, Human, Recombinant (His & MBP)

TMPY-02595

Species: Human

Expression System: E. coli

SIRP beta 1 Protein, Mouse, Recombinant (His)

TMPY-02388

Species: Mouse

Expression System: HEK293 Cells

EphB2 Protein, Human, Recombinant (hFc)

TMPJ-00424

Species: Human

Expression System: HEK293 Cells

NRG1 beta 1 Protein, Human, Recombinant (aa 2-246)

TMPJ-00448

Species: Human

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (His & Avi)

TMPK-00455

Species: Human

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)

TMPK-00658

Species: Cynomolgus

Expression System: HEK293 Cells

IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated

TMPK-00456

Species: Human

Expression System: HEK293 Cells

VSTM1 Protein, Human, Recombinant (His)

TMPY-02555

Species: Human

Expression System: HEK293 Cells

VSTM1 Protein, Human, Recombinant (hFc)

TMPY-02563

Species: Human

Expression System: HEK293 Cells

EphB1 Protein, Human, Recombinant (hFc)

TMPJ-00403

Species: Human

Expression System: HEK293 Cells

PIP4K2A Protein, Human, Recombinant (His)

TMPJ-00978

Species: Human

Expression System: HEK293 Cells

MPZL1 Protein, Human, Recombinant (His)

TMPJ-00712

Species: Human

Expression System: HEK293 Cells

EFNB2 Protein, Mouse, Recombinant (hFc & His)

TMPJ-00224

Species: Mouse

Expression System: HEK293 Cells

WIF1 Protein, Mouse, Recombinant (His)

TMPY-02849

Species: Mouse

Expression System: HEK293 Cells

GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)

TMPJ-00290

Species: Human

Expression System: HEK293 Cells

FGF-19 Protein, Human, Recombinant (His)

TMPJ-00715

Species: Human

Expression System: E. coli

CSF1R Protein, Cynomolgus, Recombinant (hFc)

TMPJ-01418

Species: Cynomolgus

Expression System: HEK293 Cells

CSF1R Protein, Cynomolgus, Recombinant (His)

TMPJ-01419

Species: Cynomolgus

Expression System: HEK293 Cells

Neurturin Protein, Human, Recombinant

TMPJ-01290

Species: Human

Expression System: E. coli

AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

TMPY-04451

Species: Human

Expression System: Baculovirus Insect Cells

CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)

TMPY-03745

Species: Human

Expression System: HEK293 Cells

Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

TMPY-03878

Species: Human

Expression System: HEK293 Cells

CD3D & CD3E Heterodimer Protein, Human, Recombinant

TMPY-02501

Species: Human

Expression System: HEK293 Cells

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カタログ番号	製品名
L9410	Covalent Inhibitor Library		1920 compounds
	A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.

ライブラリー

Covalent Inhibitor Library

L9410

Compounds: 1920